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Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition

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dc.contributor.authorIssa, Fatiah
dc.contributor.authorKassiou, Michael
dc.contributor.authorChan, Hak-Kim
dc.contributor.authorMcLeod, Malcolm
dc.date.accessioned2015-12-10T22:23:37Z
dc.date.issued2006
dc.date.updated2015-12-09T09:09:45Z
dc.description.abstractIpratropium bromide [(1R,3r,5S,8r,2′RS)-3-(3′-hydroxy-2′- phenylpropionyloxy)-8-isopropyl-8-methyl-8-aza-bicyclo[3.2.1]octan-8-ium bromide] and tiotropium bromide [(1R,2R,4S,5S,7s)-7-[2′-hydroxy-2′, 2′-di(thiophen2″-yl)acetoxy]-9,9-dimethyl-
dc.identifier.issn0004-9425
dc.identifier.urihttp://hdl.handle.net/1885/52882
dc.publisherCSIRO Publishing
dc.sourceAustralian Journal of Chemistry
dc.subjectKeywords: Amines; Aromatic compounds; Bromine compounds; Positron emission tomography; Pulmonary diseases; Synthesis (chemical); Drug deposition; Ipratropium; Radiochemical purity; Radioligands; Drug products
dc.titleSynthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage58
local.bibliographicCitation.startpage53
local.contributor.affiliationIssa, Fatiah, University of Sydney
local.contributor.affiliationKassiou, Michael, University of Sydney
local.contributor.affiliationChan, Hak-Kim, University of Sydney
local.contributor.affiliationMcLeod, Malcolm, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidMcLeod, Malcolm, u4045340
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationu4005981xPUB258
local.identifier.citationvolume59
local.identifier.doi10.1071/CH05303
local.identifier.scopusID2-s2.0-31744440587
local.type.statusPublished Version

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