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Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition

Date

Authors

Issa, Fatiah

Kassiou, Michael

Chan, Hak-Kim

McLeod, Malcolm

Publisher

CSIRO Publishing

Abstract

Ipratropium bromide [(1R,3r,5S,8r,2′RS)-3-(3′-hydroxy-2′- phenylpropionyloxy)-8-isopropyl-8-methyl-8-aza-bicyclo[3.2.1]octan-8-ium bromide] and tiotropium bromide [(1R,2R,4S,5S,7s)-7-[2′-hydroxy-2′, 2′-di(thiophen2″-yl)acetoxy]-9,9-dimethyl-

Keywords

Keywords: Amines; Aromatic compounds; Bromine compounds; Positron emission tomography; Pulmonary diseases; Synthesis (chemical); Drug deposition; Ipratropium; Radiochemical purity; Radioligands; Drug products

URI

http://hdl.handle.net/1885/52882

Collections

ANU Research Publications

Source

Australian Journal of Chemistry

Type

Journal article

DOI

10.1071/CH05303

Restricted until

2037-12-31

Downloads

File

Description

01_Issa_Synthesis_and_radiolabelling_2006.pdf (201.34 KB)

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