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Synthesis of quaternised 2-aminopyrimido[4,5- d ]pyrimidin-4(3 H )-ones and their biological activity with dihydrofolate reductase

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dc.contributor.authorGebauer, Markus
dc.contributor.authorMcKinlay, Carolyn
dc.contributor.authorGready, Jill
dc.date.accessioned2015-12-13T22:31:37Z
dc.date.available2015-12-13T22:31:37Z
dc.date.issued2003
dc.date.updated2015-12-11T09:01:51Z
dc.description.abstractIn a program to design and develop mechanism-based compounds active as substrates and inhibitors of dihydrofolate reductase (DHFR), we report the synthesis and physical properties of the 6-methyl- (7), 8-methyl- (8a), and 8-ethyl- (8b) derivatives of the
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/1885/75339
dc.publisherElsevier
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectKeywords: 2 aminopyrimido[4,5 d]pyrimidin 4(3h) one; 2,4 diamino 3 methyliminomethylpyrimidin 6(1h) one; 6 methyl 2 aminopyrimido[4,5 d]pyrimidin 4(6h) one; 8 ethyl 2 aminopyrimido[4,5 d]pyrimidin 4(8h) one; 8 methyl 2 aminopyrimido[4,5 d]pyrimidin 4(8h) one; dihyd Alkyl-pyrimido[4,5-d]pyrimidine; Antifolate; Dihydrofolate reductase; Pterin; Substrates
dc.titleSynthesis of quaternised 2-aminopyrimido[4,5- d ]pyrimidin-4(3 H )-ones and their biological activity with dihydrofolate reductase
dc.typeJournal article
local.bibliographicCitation.lastpage728
local.bibliographicCitation.startpage719
local.contributor.affiliationGebauer, Markus, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMcKinlay, Carolyn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGready, Jill, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidGebauer, Markus, u960687
local.contributor.authoruidMcKinlay, Carolyn, u4162513
local.contributor.authoruidGready, Jill, u9508375
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub4579
local.identifier.citationvolume38
local.identifier.doi10.1016/S0223-5234(03)00140-5
local.identifier.scopusID2-s2.0-0042657901
local.type.statusPublished Version

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