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Synthesis of quaternised 2-aminopyrimido[4,5- d ]pyrimidin-4(3 H )-ones and their biological activity with dihydrofolate reductase

Date

Authors

Gebauer, Markus

McKinlay, Carolyn

Gready, Jill

Publisher

Elsevier

Abstract

In a program to design and develop mechanism-based compounds active as substrates and inhibitors of dihydrofolate reductase (DHFR), we report the synthesis and physical properties of the 6-methyl- (7), 8-methyl- (8a), and 8-ethyl- (8b) derivatives of the

Keywords

Keywords: 2 aminopyrimido[4,5 d]pyrimidin 4(3h) one; 2,4 diamino 3 methyliminomethylpyrimidin 6(1h) one; 6 methyl 2 aminopyrimido[4,5 d]pyrimidin 4(6h) one; 8 ethyl 2 aminopyrimido[4,5 d]pyrimidin 4(8h) one; 8 methyl 2 aminopyrimido[4,5 d]pyrimidin 4(8h) one; dihyd Alkyl-pyrimido[4,5-d]pyrimidine; Antifolate; Dihydrofolate reductase; Pterin; Substrates

URI

http://hdl.handle.net/1885/75339

Collections

ANU Research Publications

Source

European Journal of Medicinal Chemistry

Type

Journal article

DOI

10.1016/S0223-5234(03)00140-5

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