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DNA binding of the anti-cancer platinum complex trans -[{Pt(NH 3 ) 2 Cl} 2 μ-dpzm] 2+

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dc.contributor.authorWheate, Nial
dc.contributor.authorEvison, Ben
dc.contributor.authorHerlt, Anthony
dc.contributor.authorPhillips, Don
dc.contributor.authorCollins, John
dc.date.accessioned2015-12-13T23:08:14Z
dc.date.available2015-12-13T23:08:14Z
dc.date.issued2003
dc.date.updated2015-12-12T08:12:40Z
dc.description.abstractThe DNA binding of the dinuclear platinum complex trans-[{Pt(NH 3)2Cl}2μ-dpzm]2+ (di-Pt), linked with the 4,4′-dipyrazolylmethane (dpzm) linker, was examined by 1H and 195Pt NMR and transcription assays. At 60 °C, di-Pt reacts with guanosine two-fold
dc.identifier.issn1477-9226
dc.identifier.urihttp://hdl.handle.net/1885/86583
dc.publisherRoyal Society of Chemistry
dc.sourceDalton Transactions
dc.subjectKeywords: Bioassay; Chemical bonds; Complexation; DNA; Drug products; High performance liquid chromatography; Nuclear magnetic resonance spectroscopy; Oncology; Platinum compounds; Anti-cancer agents; Organometallics
dc.titleDNA binding of the anti-cancer platinum complex trans -[{Pt(NH 3 ) 2 Cl} 2 μ-dpzm] 2+
dc.typeJournal article
local.bibliographicCitation.issue18
local.bibliographicCitation.lastpage3492
local.bibliographicCitation.startpage3486
local.contributor.affiliationWheate, Nial, University of New South Wales, ADFA
local.contributor.affiliationEvison, Ben, La Trobe University
local.contributor.affiliationHerlt, Anthony, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationPhillips, Don, La Trobe University
local.contributor.affiliationCollins, John, University of New South Wales
local.contributor.authoruidHerlt, Anthony, u7100439
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030201 - Bioinorganic Chemistry
local.identifier.ariespublicationMigratedxPub15496
local.identifier.scopusID2-s2.0-0141921868
local.type.statusPublished Version

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