Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

DNA binding of the anti-cancer platinum complex trans -[{Pt(NH 3 ) 2 Cl} 2 μ-dpzm] 2+

Thumbnail Image

Date

2003

Authors

Wheate, Nial
Evison, Ben
Herlt, Anthony
Phillips, Don
Collins, John

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

The DNA binding of the dinuclear platinum complex trans-[{Pt(NH 3)2Cl}2μ-dpzm]2+ (di-Pt), linked with the 4,4′-dipyrazolylmethane (dpzm) linker, was examined by 1H and 195Pt NMR and transcription assays. At 60 °C, di-Pt reacts with guanosine two-fold

Description

Keywords

Keywords: Bioassay; Chemical bonds; Complexation; DNA; Drug products; High performance liquid chromatography; Nuclear magnetic resonance spectroscopy; Oncology; Platinum compounds; Anti-cancer agents; Organometallics

Citation

URI

http://hdl.handle.net/1885/86583

Collections

ANU Research Publications

Source

Dalton Transactions

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

DSpace software copyright © 2002-2026 LYRASIS