DNA binding of the anti-cancer platinum complex trans -[{Pt(NH 3 ) 2 Cl} 2 μ-dpzm] 2+
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Wheate, Nial
Evison, Ben
Herlt, Anthony
Phillips, Don
Collins, John
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Royal Society of Chemistry
Abstract
The DNA binding of the dinuclear platinum complex trans-[{Pt(NH 3)2Cl}2μ-dpzm]2+ (di-Pt), linked with the 4,4′-dipyrazolylmethane (dpzm) linker, was examined by 1H and 195Pt NMR and transcription assays. At 60 °C, di-Pt reacts with guanosine two-fold
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Dalton Transactions