Human DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase

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dc.contributor.authorFranklin, Andrew
dc.contributor.authorMilburn, Peter J
dc.contributor.authorBlanden, Robert
dc.contributor.authorSteele, Edward J
dc.date.accessioned2015-12-13T22:40:59Z
dc.date.available2015-12-13T22:40:59Z
dc.date.issued2004
dc.date.updated2015-12-11T09:58:22Z
dc.description.abstractWe have proposed previously that error-prone reverse transcription using pre-mRNA of rearranged immunoglobulin variable (IgV) regions as templates is involved in the antibody diversifying mechanism of somatic hypermutation (SHM). As patients deficient in
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/78292
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: complementary DNA; DNA directed DNA polymerase beta; DNA directed DNA polymerase eta; DNA polymerase; fluorescent dye; nucleotide; RNA directed DNA polymerase; unclassified drug; article; DNA determination; enzyme activity; enzyme assay; immunoglobulin ge Affinity maturation; Human DNA polymerase-?; Immunoglobulin variable region genes; Reverse transcription; Somatic hypermutation
dc.titleHuman DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage225
local.bibliographicCitation.startpage219
local.contributor.affiliationFranklin, Andrew, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMilburn, Peter J, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBlanden, Robert, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSteele, Edward J, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu8707729@anu.edu.au
local.contributor.authoruidFranklin, Andrew, u9913738
local.contributor.authoruidMilburn, Peter J, u8707729
local.contributor.authoruidBlanden, Robert, u7100504
local.contributor.authoruidSteele, Edward J, a145554
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110706 - Immunogenetics (incl. Genetic Immunology)
local.identifier.ariespublicationMigratedxPub6958
local.identifier.citationvolume82
local.identifier.doi10.1046/j.0818-9641.2004.01221.x
local.identifier.scopusID2-s2.0-2342652151
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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