Human DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
Date
2004
Authors
Franklin, Andrew
Milburn, Peter J
Blanden, Robert
Steele, Edward J
Journal Title
Journal ISSN
Volume Title
Publisher
Blackwell Publishing Ltd
Abstract
We have proposed previously that error-prone reverse transcription using pre-mRNA of rearranged immunoglobulin variable (IgV) regions as templates is involved in the antibody diversifying mechanism of somatic hypermutation (SHM). As patients deficient in
Description
Keywords
Keywords: complementary DNA; DNA directed DNA polymerase beta; DNA directed DNA polymerase eta; DNA polymerase; fluorescent dye; nucleotide; RNA directed DNA polymerase; unclassified drug; article; DNA determination; enzyme activity; enzyme assay; immunoglobulin ge Affinity maturation; Human DNA polymerase-?; Immunoglobulin variable region genes; Reverse transcription; Somatic hypermutation
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Source
Immunology and Cell Biology
Type
Journal article