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Human DNA polymerase-η, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase

Date

Authors

Franklin, Andrew

Milburn, Peter J

Blanden, Robert

Steele, Edward J

Publisher

Blackwell Publishing Ltd

Abstract

We have proposed previously that error-prone reverse transcription using pre-mRNA of rearranged immunoglobulin variable (IgV) regions as templates is involved in the antibody diversifying mechanism of somatic hypermutation (SHM). As patients deficient in

Keywords

Keywords: complementary DNA; DNA directed DNA polymerase beta; DNA directed DNA polymerase eta; DNA polymerase; fluorescent dye; nucleotide; RNA directed DNA polymerase; unclassified drug; article; DNA determination; enzyme activity; enzyme assay; immunoglobulin ge Affinity maturation; Human DNA polymerase-?; Immunoglobulin variable region genes; Reverse transcription; Somatic hypermutation

URI

http://hdl.handle.net/1885/78292

Collections

ANU Research Publications

Source

Immunology and Cell Biology

Type

Journal article

DOI

10.1046/j.0818-9641.2004.01221.x

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