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The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase

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dc.contributor.authorTopf, Maya
dc.contributor.authorSandala, Gregory
dc.contributor.authorSmith, David
dc.contributor.authorSchofield, Christopher
dc.contributor.authorEaston, Christopher
dc.contributor.authorRadom, Leo
dc.date.accessioned2015-12-13T22:41:09Z
dc.date.available2015-12-13T22:41:09Z
dc.date.issued2004
dc.date.updated2015-12-11T09:59:51Z
dc.description.abstractHigh-level ab initio calculations have been used to study the mechanism for the conversion of (3S,5S)-carbapenam to the biologically active β-lactam antibiotic, (5R)-carbapenem, catalyzed by carbapenem synthase. This process involves epimerization at C5
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/1885/78383
dc.publisherAmerican Chemical Society
dc.sourceJournal of the American Chemical Society
dc.subjectKeywords: carbapenem; carbapenem derivative; carbapenem synthase; unclassified drug; article; calculation; catalysis; chemical reaction kinetics; enzyme analysis; epimerization; fatty acid desaturation; molecular stability; oxidation reduction reaction; reaction an
dc.titleThe Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase
dc.typeJournal article
local.bibliographicCitation.issue32
local.bibliographicCitation.lastpage9933
local.bibliographicCitation.startpage9932
local.contributor.affiliationTopf, Maya, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSandala, Gregory, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSmith, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSchofield, Christopher, University of Oxford
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationRadom, Leo, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidTopf, Maya, t450
local.contributor.authoruidSandala, Gregory, u2507541
local.contributor.authoruidSmith, David, u4593644
local.contributor.authoruidEaston, Christopher, u9500570
local.contributor.authoruidRadom, Leo, u7401603
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub7037
local.identifier.citationvolume126
local.identifier.doi10.1021/ja047899v
local.identifier.scopusID2-s2.0-4043149905
local.type.statusPublished Version

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