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The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase

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Date

2004

Authors

Topf, Maya
Sandala, Gregory
Smith, David
Schofield, Christopher
Easton, Christopher
Radom, Leo

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

High-level ab initio calculations have been used to study the mechanism for the conversion of (3S,5S)-carbapenam to the biologically active β-lactam antibiotic, (5R)-carbapenem, catalyzed by carbapenem synthase. This process involves epimerization at C5

Description

Keywords

Keywords: carbapenem; carbapenem derivative; carbapenem synthase; unclassified drug; article; calculation; catalysis; chemical reaction kinetics; enzyme analysis; epimerization; fatty acid desaturation; molecular stability; oxidation reduction reaction; reaction an

Citation

URI

http://hdl.handle.net/1885/78383

Collections

ANU Research Publications

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja047899v

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