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Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

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dc.contributor.authorMcDevitt, Christopher A.
dc.contributor.authorShintre, Chitra A.
dc.contributor.authorGrossmann, J Gunter
dc.contributor.authorPollock, Naomi L.
dc.contributor.authorPrince, Stephen
dc.contributor.authorFord, Robert C.
dc.contributor.authorCallaghan, Richard
dc.date.accessioned2015-12-13T22:17:28Z
dc.date.issued2008
dc.date.updated2015-12-11T07:34:24Z
dc.description.abstractP-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/1885/71144
dc.publisherElsevier
dc.sourceFEBS Letters
dc.subjectKeywords: glycoprotein P; article; controlled study; gel permeation chromatography; nonhuman; polyacrylamide gel electrophoresis; priority journal; protein folding; protein purification; protein structure; X ray crystallography; Bacterial Proteins; Cryoelectron Mic ABCB1; Electron crystallography; Membrane protein; Multidrug resistance; Protein structure; SAXS
dc.titleStructural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography
dc.typeJournal article
local.bibliographicCitation.issue19
local.bibliographicCitation.lastpage2956
local.bibliographicCitation.startpage2950
local.contributor.affiliationMcDevitt, Christopher A., University of Oxford
local.contributor.affiliationShintre, Chitra A., University of Manchester
local.contributor.affiliationGrossmann, J Gunter, University of Liverpool
local.contributor.affiliationPollock, Naomi L., University of Oxford
local.contributor.affiliationPrince, Stephen, University of Manchester
local.contributor.affiliationCallaghan, Richard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFord, Robert C., University of Manchester
local.contributor.authoruidCallaghan, Richard, u5103268
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060199 - Biochemistry and Cell Biology not elsewhere classified
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absfor060112 - Structural Biology (incl. Macromolecular Modelling)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationU3488905xPUB2575
local.identifier.citationvolume582
local.identifier.doi10.1016/j.febslet.2008.07.022
local.identifier.scopusID2-s2.0-48749107151
local.type.statusPublished Version

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