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Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

Date

2008

Authors

McDevitt, Christopher A.
Shintre, Chitra A.
Grossmann, J Gunter
Pollock, Naomi L.
Prince, Stephen
Ford, Robert C.
Callaghan, Richard

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.

Description

Keywords

Keywords: glycoprotein P; article; controlled study; gel permeation chromatography; nonhuman; polyacrylamide gel electrophoresis; priority journal; protein folding; protein purification; protein structure; X ray crystallography; Bacterial Proteins; Cryoelectron Mic ABCB1; Electron crystallography; Membrane protein; Multidrug resistance; Protein structure; SAXS

Citation

URI

http://hdl.handle.net/1885/71144

Collections

ANU Research Publications

Source

FEBS Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.febslet.2008.07.022

Restricted until

2037-12-31

Downloads

File
Description
01_McDevitt_Structural_insights_into_2008.pdf (1.83 MB)

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