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Extending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping

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dc.contributor.authorBogdan, Malgorzata
dc.contributor.authorFrommlet, Florian
dc.contributor.authorBiecek, Przemyslaw
dc.contributor.authorCheng, Riyan
dc.contributor.authorGhosh, Jayanta K.
dc.contributor.authorDoerge, R W
dc.date.accessioned2016-02-24T22:42:05Z
dc.date.issued2008
dc.date.updated2016-02-24T11:28:13Z
dc.description.abstractThe modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map and, more importantly, to the situation where consecutive QTL and interactions are located by multiple interval mapping. Easy to use formulas for the extended mBIC are given. A simulation study, as well as the analysis of real data, confirm the good properties of the extended mBIC.
dc.identifier.issn0006-341X
dc.identifier.urihttp://hdl.handle.net/1885/98939
dc.publisherInternational Biometrics Society
dc.sourceBiometrics
dc.subjectKeywords: Bayesian analysis; genome; mapping; model; article; Bayes theorem; computer simulation; gene mapping; genetic marker; genotype; mathematical model; quantitative trait locus; Bayes Theorem; Chromosome Mapping; Computer Simulation; Genomics; Quantitative Tr Model selection criterion; Multiple QTL; QTL interaction
dc.titleExtending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage1169
local.bibliographicCitation.startpage1162
local.contributor.affiliationBogdan, Malgorzata, Wroclaw University of Technology
local.contributor.affiliationFrommlet, Florian, Purdue University
local.contributor.affiliationBiecek, Przemyslaw, Polish Academy of Sciences
local.contributor.affiliationCheng, Riyan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGhosh, Jayanta K., Purdue University
local.contributor.affiliationDoerge, R W , Purdue University
local.contributor.authoruidCheng, Riyan, u5264559
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor010402 - Biostatistics
local.identifier.absfor060412 - Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu4956746xPUB352
local.identifier.citationvolume64
local.identifier.doi10.1111/j.1541-0420.2008.00989.x
local.identifier.scopusID2-s2.0-54949119817
local.identifier.thomsonID000261054500018
local.type.statusPublished Version

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