Extending the modified Bayesian Information Criterion (mBIC) to dense markers and multiple interval mapping

Date

2008

Authors

Bogdan, Malgorzata
Frommlet, Florian
Biecek, Przemyslaw
Cheng, Riyan
Ghosh, Jayanta K.
Doerge, R W

Journal Title

Journal ISSN

Volume Title

Publisher

International Biometrics Society

Abstract

The modified version of Bayesian Information Criterion (mBIC) is a relatively simple model selection procedure that can be used when locating multiple interacting quantitative trait loci (QTL). Our earlier work demonstrated the statistical properties of mBIC for situations where the average genetic map interval is at least 5 cM. In this work mBIC is adapted to genome searches based on a dense map and, more importantly, to the situation where consecutive QTL and interactions are located by multiple interval mapping. Easy to use formulas for the extended mBIC are given. A simulation study, as well as the analysis of real data, confirm the good properties of the extended mBIC.

Description

Keywords

Keywords: Bayesian analysis; genome; mapping; model; article; Bayes theorem; computer simulation; gene mapping; genetic marker; genotype; mathematical model; quantitative trait locus; Bayes Theorem; Chromosome Mapping; Computer Simulation; Genomics; Quantitative Tr Model selection criterion; Multiple QTL; QTL interaction

Citation

Source

Biometrics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/j.1541-0420.2008.00989.x

Restricted until

2037-12-31