Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

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dc.contributor.authorErnst-Russell, M
dc.contributor.authorElix, John
dc.contributor.authorChai, Christina
dc.contributor.authorWillis, Anthony
dc.contributor.authorHamada, Nabuo
dc.contributor.authorNash, Thomas
dc.date.accessioned2015-12-13T23:20:19Z
dc.date.issued1999
dc.date.updated2015-12-12T09:02:44Z
dc.description.abstractHybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 μM), active against the murine P815 mastocytoma cell line.
dc.identifier.issn0040-4039
dc.identifier.urihttp://hdl.handle.net/1885/90652
dc.publisherElsevier
dc.sourceTetrahedron Letters
dc.subjectKeywords: cytotoxic agent; hybocarpone; naphthazarin derivative; unclassified drug; article; carbon nuclear magnetic resonance; drug isolation; lichens; phytochemistry; proton nuclear magnetic resonance; toxin analysis; X ray diffraction; Lecanora hybocarpa; Murina
dc.titleHybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa
dc.typeJournal article
local.bibliographicCitation.lastpage6324
local.bibliographicCitation.startpage6321
local.contributor.affiliationErnst-Russell, M, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationElix, John, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationChai, Christina, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWillis, Anthony, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationHamada, Nabuo, Osaka City Institute of Public Health and Environmental Sciences
local.contributor.affiliationNash, Thomas, Arizona State University
local.contributor.authoremailu6700470@anu.edu.au
local.contributor.authoruidErnst-Russell, M, u9505025
local.contributor.authoruidElix, John, u6700470
local.contributor.authoruidChai, Christina, u8615775
local.contributor.authoruidWillis, Anthony, u8512028
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationMigratedxPub21076
local.identifier.citationvolume40
local.identifier.doi10.1016/S0040-4039(99)01220-4
local.identifier.scopusID2-s2.0-0033588204
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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