Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa
Date
1999
Authors
Ernst-Russell, M
Elix, John
Chai, Christina
Willis, Anthony
Hamada, Nabuo
Nash, Thomas
Journal Title
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Volume Title
Publisher
Elsevier
Abstract
Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 μM), active against the murine P815 mastocytoma cell line.
Description
Keywords
Keywords: cytotoxic agent; hybocarpone; naphthazarin derivative; unclassified drug; article; carbon nuclear magnetic resonance; drug isolation; lichens; phytochemistry; proton nuclear magnetic resonance; toxin analysis; X ray diffraction; Lecanora hybocarpa; Murina
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Source
Tetrahedron Letters
Type
Journal article
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2037-12-31