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Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)

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Date

2013

Authors

Sudta, Pichit
Kirk, Nicholas
Bezos, Anna
Gurlica, Anthony
Mitchell, Rhys
Weber, Thomas
Willis, Anthony
Prabpai, Samran
Kongsaeree, Palangpon
Suksamrarn, Sunit

Journal Title

Journal ISSN

Volume Title

Publisher

CSIRO Publishing

Abstract

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416

Description

Keywords

Keywords: Angiogenesis inhibitors; Anti-angiogenic activity; Anticancer drug; Fused-ring system; In-vitro models; Intra-molecular hydrogen bonds; Structural characteristics; Structural motifs; Scaffolds; Hydrocarbons

Citation

URI

http://hdl.handle.net/1885/62321

Collections

ANU Research Publications

Source

Australian Journal of Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1071/CH13219

Restricted until

2037-12-31

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Description
01_Sudta_Synthesis,_structural_2013.pdf (653.3 KB)

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