Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony; Prabpai, Samran; Kongsaeree, Palangpon; Suksamrarn, Sunit; Kelso, Michael; Parish, Christopher

Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)

Date

2013

Authors

Sudta, Pichit

Kirk, Nicholas

Bezos, Anna

Gurlica, Anthony

Mitchell, Rhys

Weber, Thomas

Willis, Anthony

Prabpai, Samran

Kongsaeree, Palangpon

Suksamrarn, Sunit

Publisher

CSIRO Publishing

Abstract

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416