Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®)
Date
2013
Authors
Sudta, Pichit
Kirk, Nicholas
Bezos, Anna
Gurlica, Anthony
Mitchell, Rhys
Weber, Thomas
Willis, Anthony
Prabpai, Samran
Kongsaeree, Palangpon
Suksamrarn, Sunit
Journal Title
Journal ISSN
Volume Title
Publisher
CSIRO Publishing
Abstract
The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent®) and predecessor angiogenesis inhibitors that have undergone anticancer clinical trials (e.g. semaxanib, SU5416
Description
Keywords
Keywords: Angiogenesis inhibitors; Anti-angiogenic activity; Anticancer drug; Fused-ring system; In-vitro models; Intra-molecular hydrogen bonds; Structural characteristics; Structural motifs; Scaffolds; Hydrocarbons
Citation
Collections
Source
Australian Journal of Chemistry
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
DOI
Restricted until
2037-12-31
Downloads
File
Description