Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

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dc.contributor.authorSutton, Vivien R
dc.contributor.authorWaterhouse, Nigel J
dc.contributor.authorBrowne, Kylie
dc.contributor.authorSedelies, Karin
dc.contributor.authorCiccone, Annette
dc.contributor.authorAnthony, Desiree A
dc.contributor.authorKoskinen, Aulikki
dc.contributor.authorMullbacher, Arno
dc.contributor.authorTrapani, Joseph A
dc.date.accessioned2015-12-07T22:42:42Z
dc.date.issued2007
dc.date.updated2015-12-07T11:10:48Z
dc.description.abstractCathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C-null mice are therefore proposed to totally lack granzyme B activity and
dc.identifier.issn0021-9525
dc.identifier.urihttp://hdl.handle.net/1885/24653
dc.publisherRockefeller University Press
dc.sourceJournal of Cell Biology
dc.subjectKeywords: dipeptidyl peptidase I; granzyme B; perforin; animal cell; animal experiment; animal model; apoptosis; article; CD8+ T lymphocyte; controlled study; Ectromelia virus; enzyme activity; enzyme inactivation; in vivo study; mouse; nonhuman; priority journal;
dc.titleResidual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage433
local.bibliographicCitation.startpage425
local.contributor.affiliationSutton, Vivien R, Peter MacCallum Cancer Centre
local.contributor.affiliationWaterhouse, Nigel J, Peter MacCallum Cancer Centre
local.contributor.affiliationBrowne, Kylie, Peter MacCallum Cancer Centre
local.contributor.affiliationSedelies, Karin, Peter MacCallum Cancer Centre
local.contributor.affiliationCiccone, Annette, Peter MacCallum Cancer Centre
local.contributor.affiliationAnthony, Desiree A, Peter MacCallum Cancer Centre
local.contributor.affiliationKoskinen, Aulikki, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMullbacher, Arno, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTrapani, Joseph A, Peter MacCallum Cancer Centre
local.contributor.authoruidKoskinen, Aulikki, u9108883
local.contributor.authoruidMullbacher, Arno, u8102295
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB33
local.identifier.citationvolume176
local.identifier.doi10.1083/jcb.200609077
local.identifier.scopusID2-s2.0-33846990905
local.type.statusPublished Version

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