Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Sutton, Vivien R; Waterhouse, Nigel J; Browne, Kylie; Sedelies, Karin; Ciccone, Annette; Anthony, Desiree A; Koskinen, Aulikki; Mullbacher, Arno; Trapani, Joseph A

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Date

2007

Authors

Sutton, Vivien R

Waterhouse, Nigel J

Browne, Kylie

Sedelies, Karin

Ciccone, Annette

Anthony, Desiree A

Koskinen, Aulikki

Mullbacher, Arno

Trapani, Joseph A

Publisher

Rockefeller University Press

Abstract

Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C-null mice are therefore proposed to totally lack granzyme B activity and