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Regulation of MicroRNA by Antagomirs: A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function?

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dc.contributor.authorMattes, Joerg
dc.contributor.authorYang, Ming
dc.contributor.authorFoster, Paul S
dc.date.accessioned2015-12-07T22:25:45Z
dc.date.issued2007
dc.date.updated2015-12-07T09:40:44Z
dc.description.abstractThe discovery of small "noncoding" or "nonmessenger" RNA molecules that are repressors of translation (microRNAs) has provided the opportunity to specifically suppress a gene or clusters of genes. Moreover, the recent employment of synthetic analogs of these small RNA molecules termed "antagomirs" has shown that microRNAs of interest can be specifically targeted. Understanding the role of microRNAs in fundamental processes associated with complex diseases such as asthma, chronic obstructive pulmonary disease, cancer, chronic infections, and immune disorders may aid in disease diagnosis and prognosis and potentially identify new therapeutic targets.
dc.identifier.issn1044-1549
dc.identifier.urihttp://hdl.handle.net/1885/21447
dc.publisherAmerican Thoracic Society
dc.sourceAmerican Journal of Respiratory Cell and Molecular Biology
dc.subjectKeywords: antagomir; microRNA; oligonucleotide; small interfering RNA; unclassified drug; untranslated RNA; asthma; cancer; chronic obstructive lung disease; disease association; gene cluster; gene control; gene expression regulation; gene repression; human; immune
dc.titleRegulation of MicroRNA by Antagomirs: A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function?
dc.typeJournal article
local.bibliographicCitation.lastpage12
local.bibliographicCitation.startpage8
local.contributor.affiliationMattes, Joerg, University of Newcastle
local.contributor.affiliationYang, Ming, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFoster, Paul S, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidYang, Ming, u4003214
local.contributor.authoruidFoster, Paul S, u8800551
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110706 - Immunogenetics (incl. Genetic Immunology)
local.identifier.ariespublicationu4020362xPUB17
local.identifier.citationvolume36
local.identifier.doi10.1165/rcmb.2006-0227TR
local.identifier.scopusID2-s2.0-33846083393
local.type.statusPublished Version

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