Regulation of MicroRNA by Antagomirs: A New Class of Pharmacological Antagonists for the Specific Regulation of Gene Function?
Date
2007
Authors
Mattes, Joerg
Yang, Ming
Foster, Paul S
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Publisher
American Thoracic Society
Abstract
The discovery of small "noncoding" or "nonmessenger" RNA molecules that are repressors of translation (microRNAs) has provided the opportunity to specifically suppress a gene or clusters of genes. Moreover, the recent employment of synthetic analogs of these small RNA molecules termed "antagomirs" has shown that microRNAs of interest can be specifically targeted. Understanding the role of microRNAs in fundamental processes associated with complex diseases such as asthma, chronic obstructive pulmonary disease, cancer, chronic infections, and immune disorders may aid in disease diagnosis and prognosis and potentially identify new therapeutic targets.
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Keywords
Keywords: antagomir; microRNA; oligonucleotide; small interfering RNA; unclassified drug; untranslated RNA; asthma; cancer; chronic obstructive lung disease; disease association; gene cluster; gene control; gene expression regulation; gene repression; human; immune
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Source
American Journal of Respiratory Cell and Molecular Biology
Type
Journal article
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2037-12-31
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