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SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

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Date

2020

Authors

Furuya, Yoichi
Mullbacher, Arno
Pardo, Julian

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

Despite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.

Description

Keywords

SARS-CoV-2, COVID-19, Gamma-ray, irradiated vaccine

Citation

URI

https://hdl.handle.net/1885/733721264

Collections

ANU Research Publications

Source

Pathogens

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

Creative Commons Attribution 4.0 International License

DOI

10.3390/pathogens9110928

Restricted until

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pathogens-09-00928.pdf (162.7 KB)

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