SARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity

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dc.contributor.authorFuruya, Yoichi
dc.contributor.authorMullbacher, Arno
dc.contributor.authorPardo, Julian
dc.date.accessioned2024-10-04T04:56:37Z
dc.date.available2024-10-04T04:56:37Z
dc.date.issued2020
dc.date.updated2024-03-03T07:16:30Z
dc.description.abstractDespite accumulating preclinical data demonstrating a crucial role of cytotoxic T cell immunity during viral infections, ongoing efforts on developing COVID-19 vaccines are mostly focused on antibodies. In this commentary article, we discuss potential benefits of cytotoxic T cells in providing long-term protection against COVID-19. Further, we propose that gamma-ray irradiation, which is a previously tested inactivation method, may be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity involving both B and T cells.
dc.description.sponsorshipY.F. is supported by American Heart Association Scientist Development Grant (17SDG33630188) and NIH (1R56AI146434-01). J.P. is supported by Health Institute Carlos III (Fondo-COVID19); Ministry of Science, Innovation, and Universities (SAF2017-83120-C2-1-R); and by Aragon Government (Group B29_17R).
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2076-0817
dc.identifier.urihttps://hdl.handle.net/1885/733721264
dc.language.isoen_AUen_AU
dc.provenanceThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.publisherMDPI
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights.licenseCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePathogens
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectGamma-ray
dc.subjectirradiated vaccine
dc.titleSARS-CoV-2 vaccines: Inactivation by gamma irradiation for T and B cell immunity
dc.typeJournal article
dcterms.accessRightsOpen Access
local.bibliographicCitation.issue11
local.bibliographicCitation.lastpage5
local.bibliographicCitation.startpage1
local.contributor.affiliationFuruya, Yoichi, College of Health and Medicine, ANU
local.contributor.affiliationMullbacher, Arno, College of Health and Medicine, ANU
local.contributor.affiliationPardo, Julian, University of Zaragoza
local.contributor.authoremailu8102295@anu.edu.au
local.contributor.authoruidFuruya, Yoichi, u4300289
local.contributor.authoruidMullbacher, Arno, u8102295
local.description.notesImported from ARIES
local.identifier.absfor320499 - Immunology not elsewhere classified
local.identifier.absfor320400 - Immunology
local.identifier.ariespublicationa383154xPUB16170
local.identifier.citationvolume9
local.identifier.doi10.3390/pathogens9110928
local.identifier.scopusID2-s2.0-85095773498
local.identifier.thomsonIDWOS:000594411900001
local.identifier.uidSubmittedBya383154
local.publisher.urlhttps://www.mdpi.com/2076-0817/9/11/928
local.type.statusPublished Version
publicationvolume.volumeNumber9

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