Specific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process

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dc.contributor.authorWahlstrom, Anna
dc.contributor.authorCukalevski, Risto
dc.contributor.authorDanielsson, Jens
dc.contributor.authorJarvet, Juri
dc.contributor.authorOnagi, Hideki
dc.contributor.authorRebek, Julius (Jr.)
dc.contributor.authorLinse, Sara
dc.contributor.authorGraslund, Astrid
dc.date.accessioned2015-12-10T23:00:56Z
dc.date.issued2012
dc.date.updated2016-02-24T10:25:21Z
dc.description.abstractAlzheimer's disease involves progressive neuronal loss. Linked to the disease is the amyloid β (Aβ) peptide, a 38-43-amino acid peptide found in extracellular amyloid plaques in the brain. Cyclodextrins are nontoxic, cone-shaped oligosaccharides with a
dc.identifier.issn0006-2960
dc.identifier.urihttp://hdl.handle.net/1885/61556
dc.publisherAmerican Chemical Society
dc.sourceBiochemistry
dc.subjectKeywords: Aggregation process; Alzheimer's disease; Amyloid plaques; Apparent k; Aromatic guests; Cone-shaped; Cyclodextrin dimers; Dissociation constant; Extracellular; Fibrillar aggregates; Flexible linkers; Heteronuclear; High concentration; Hydrophobic cavities
dc.titleSpecific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process
dc.typeJournal article
local.bibliographicCitation.issue21
local.bibliographicCitation.lastpage4289
local.bibliographicCitation.startpage4280
local.contributor.affiliationWahlstrom, Anna, Stockholm University
local.contributor.affiliationCukalevski, Risto, Lund University
local.contributor.affiliationDanielsson, Jens, Stockholm University
local.contributor.affiliationJarvet, Juri, National Institute of Chemical Physics and Biophysics
local.contributor.affiliationOnagi, Hideki, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationRebek, Julius (Jr.), Scripps Research Institute
local.contributor.affiliationLinse, Sara, Lund University
local.contributor.affiliationGraslund, Astrid, Stockholm University
local.contributor.authoremailu9718356@anu.edu.au
local.contributor.authoruidOnagi, Hideki, u9718356
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030302 - Nanochemistry and Supramolecular Chemistry
local.identifier.absseo860699 - Industrial Chemicals and Related Products not elsewhere classified
local.identifier.ariespublicationu4005981xPUB620
local.identifier.citationvolume51
local.identifier.doi10.1021/bi300341j
local.identifier.scopusID2-s2.0-84861591086
local.identifier.thomsonID000304492500006
local.identifier.uidSubmittedByu4005981
local.type.statusPublished Version

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