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Specific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process

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Date

2012

Authors

Wahlstrom, Anna
Cukalevski, Risto
Danielsson, Jens
Jarvet, Juri
Onagi, Hideki
Rebek, Julius (Jr.)
Linse, Sara
Graslund, Astrid

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Alzheimer's disease involves progressive neuronal loss. Linked to the disease is the amyloid β (Aβ) peptide, a 38-43-amino acid peptide found in extracellular amyloid plaques in the brain. Cyclodextrins are nontoxic, cone-shaped oligosaccharides with a

Description

Keywords

Keywords: Aggregation process; Alzheimer's disease; Amyloid plaques; Apparent k; Aromatic guests; Cone-shaped; Cyclodextrin dimers; Dissociation constant; Extracellular; Fibrillar aggregates; Flexible linkers; Heteronuclear; High concentration; Hydrophobic cavities

Citation

URI

http://hdl.handle.net/1885/61556

Collections

ANU Research Publications

Source

Biochemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/bi300341j

Restricted until

2037-12-31

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Description
01_Wahlstrom_Specific_binding_of_a_2012.pdf (3 MB)

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