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Hypertolerance to morphine in G(zalpha)-deficient mice

Date

Authors

Hendry, Ian

Kelleher, Kim

Bartlett, Selena

Leck, Kwong-Joo

Reynolds, Anna

Heydon, Katharina

Mellick, A

Megirian, David

Matthaei, Klaus

Publisher

Elsevier

Abstract

Our laboratory has generated a mouse deficient in the alpha (α) subunit of the G protein, G(z), (G(zα)) gene and we have examined the involvement of G(zα) in spinal and supraspinal analgesia and tolerance mechanisms. Spinal analgesia was tested by the

Keywords

Keywords: delta opiate receptor; guanine nucleotide binding protein; morphine; mu opiate receptor; protein subunit; analgesia; animal experiment; animal tissue; article; controlled study; hot plate test; morphine tolerance; mouse; nonhuman; priority journal; reacti Analgesia; Behavioral testing; G protein; G(za)-deficient mice; G(z); Morphine tolerance; Opioid receptor

URI

http://hdl.handle.net/1885/89026

Collections

ANU Research Publications

Source

Brain Research

Type

Journal article

DOI

10.1016/S0006-8993(00)02387-8

Restricted until

2037-12-31

Downloads

File

Description

01_Hendry_Hypertolerance_to_morphine_in_2000.pdf (783.04 KB)

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