Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

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dc.contributor.authorRandall, Katrina
dc.contributor.authorLambe, Teresa
dc.contributor.authorJohnson, Andy L
dc.contributor.authorTreanor, Bebhinn
dc.contributor.authorKucharska, Edyta
dc.contributor.authorDomaschenz, Heather
dc.contributor.authorWhittle, Belinda
dc.contributor.authorTze, Lina
dc.contributor.authorEnders, Anselm
dc.contributor.authorCrockford, Tanya
dc.contributor.authorBouriez-Jones, Tiphaine
dc.contributor.authorAlston, Duncan
dc.contributor.authorCyster, Jason G
dc.contributor.authorLenardo, Michael J.
dc.contributor.authorMackay, Fabienne
dc.contributor.authorDennick, Elissa K.
dc.contributor.authorTangye, Stuart
dc.contributor.authorChan, Tyani D.
dc.contributor.authorCamidge, Tahra
dc.contributor.authorBrink, Robert
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.contributor.authorBatista, Facundo D.
dc.contributor.authorCornall, Richard J
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-08T22:24:54Z
dc.date.issued2009
dc.date.updated2016-02-24T11:38:19Z
dc.description.abstractTo identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/1885/33188
dc.publisherNature Publishing Group
dc.sourceNature Immunology
dc.subjectKeywords: B lymphocyte receptor; intercellular adhesion molecule 1; protein Dock8; Rac protein; Rho factor; unclassified drug; animal cell; animal experiment; animal model; antibody production; antibody response; article; B lymphocyte; cell survival; controlled stu
dc.titleDock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
dc.typeJournal article
local.bibliographicCitation.issue12
local.bibliographicCitation.lastpage1291
local.bibliographicCitation.startpage1283
local.contributor.affiliationRandall, Katrina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLambe, Teresa, Oxford University
local.contributor.affiliationJohnson, Andy L, Oxford University
local.contributor.affiliationTreanor, Bebhinn, London Research Institute
local.contributor.affiliationKucharska, Edyta, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDomaschenz, Heather, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWhittle, Belinda, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTze, Lina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationEnders, Anselm, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCrockford, Tanya, University of Oxford
local.contributor.affiliationBouriez-Jones, Tiphaine, Oxford University
local.contributor.affiliationAlston, Duncan, Oxford University
local.contributor.affiliationCyster, Jason G, University of California
local.contributor.affiliationLenardo, Michael J., National Institutes of Health
local.contributor.affiliationMackay, Fabienne, Monash University
local.contributor.affiliationDennick, Elissa K., Garvan Institute of Medical Research
local.contributor.affiliationTangye, Stuart, Garvan Institute of Medical Research
local.contributor.affiliationChan, Tyani D., Garvan Institute of Medical Research
local.contributor.affiliationCamidge, Tahra, Garvan Institute of Medical Research
local.contributor.affiliationBrink, Robert, Garvan Institute of Medical Research
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBatista, Facundo D., London Research Institute
local.contributor.affiliationCornall, Richard J, Oxford University
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidRandall, Katrina, u4259040
local.contributor.authoruidKucharska, Edyta, u9716162
local.contributor.authoruidDomaschenz, Heather, u4032847
local.contributor.authoruidWhittle, Belinda, u9503602
local.contributor.authoruidTze, Lina, u4079707
local.contributor.authoruidEnders, Anselm, u4265664
local.contributor.authoruidGarcia De Vinuesa, Maria Carola, u4164556
local.contributor.authoruidGoodnow, Christopher, u9710462
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB99
local.identifier.citationvolume10
local.identifier.doi10.1038/ni.1820
local.identifier.scopusID2-s2.0-70449718702
local.identifier.thomsonID000271872800012
local.type.statusPublished Version

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