Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production
Date
Authors
Randall, Katrina
Lambe, Teresa
Johnson, Andy L
Treanor, Bebhinn
Kucharska, Edyta
Domaschenz, Heather
Whittle, Belinda
Tze, Lina
Enders, Anselm
Crockford, Tanya
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had
Description
Citation
Collections
Source
Nature Immunology
Type
Book Title
Entity type
Access Statement
License Rights
DOI
Restricted until
2037-12-31
Downloads
File
Description