An asymmetric synthesis of ADDA and ADDA-glycine dipeptide using the b-lactam synthon method

Cundy, Darren; Donohue, Anthony; McCarthy, Thomas D

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An asymmetric synthesis of ADDA and ADDA-glycine dipeptide using the b-lactam synthon method

Date

1999

Authors

Cundy, Darren

Donohue, Anthony

McCarthy, Thomas D

Publisher

Royal Society of Chemistry

Abstract

The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.

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http://hdl.handle.net/1885/93773

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ANU Research Publications

Source

Royal Chemical Society Journal Perkin Transactions

Type

Journal article

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An asymmetric synthesis of ADDA and ADDA-glycine dipeptide using the b-lactam synthon method

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