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Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations

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dc.contributor.authorLamontagne, Julien
dc.contributor.authorPepin, Emilie
dc.contributor.authorPeyot, Marie-Line
dc.contributor.authorJoly, Erik
dc.contributor.authorRuderman, Neil
dc.contributor.authorPoitout, Vincent
dc.contributor.authorMadiraju, Murthy S R
dc.contributor.authorNolan, Christopher
dc.contributor.authorPrentki, Marc
dc.date.accessioned2015-12-10T21:54:11Z
dc.date.issued2009
dc.date.updated2016-02-24T10:40:53Z
dc.description.abstractThiazolidinediones (TZDs) have beneficial effects on glucose homeostasis via enhancement of insulin sensitivity and preservation of β-cell function. How TZDs preserve β-cells is uncertain, but it might involve direct effects via both peroxisome prolifer
dc.identifier.issn0013-7227
dc.identifier.urihttp://hdl.handle.net/1885/38830
dc.publisherEndocrine Society (USA)
dc.sourceEndocrinology
dc.subjectKeywords: adenosine triphosphate; antidiabetic agent; berberine; compound c; enzyme inhibitor; fatty acid; glucose; hydroxymethylglutaryl coenzyme A reductase kinase; metformin; palmitic acid; pioglitazone; unclassified drug; animal cell; article; controlled study;
dc.titlePioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations
dc.typeJournal article
local.bibliographicCitation.issue8
local.bibliographicCitation.lastpage3474
local.bibliographicCitation.startpage3465
local.contributor.affiliationLamontagne, Julien, Universite de Montreal
local.contributor.affiliationPepin, Emilie, University of Montreal
local.contributor.affiliationPeyot, Marie-Line, University of Montreal
local.contributor.affiliationJoly, Erik, University of Montreal
local.contributor.affiliationRuderman, Neil, Boston Medical Centre
local.contributor.affiliationPoitout, Vincent, University of Washington
local.contributor.affiliationMadiraju, Murthy S R, University of Montreal
local.contributor.affiliationNolan, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPrentki, Marc, University of Montreal
local.contributor.authoruidNolan, Christopher, u1820721
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110306 - Endocrinology
local.identifier.ariespublicationu4201517xPUB167
local.identifier.citationvolume150
local.identifier.doi10.1210/en.2008-1557
local.identifier.scopusID2-s2.0-67651154419
local.identifier.thomsonID000268158400007
local.type.statusPublished Version

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