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Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations

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Date

2009

Authors

Lamontagne, Julien
Pepin, Emilie
Peyot, Marie-Line
Joly, Erik
Ruderman, Neil
Poitout, Vincent
Madiraju, Murthy S R
Nolan, Christopher
Prentki, Marc

Journal Title

Journal ISSN

Volume Title

Publisher

Endocrine Society (USA)

Abstract

Thiazolidinediones (TZDs) have beneficial effects on glucose homeostasis via enhancement of insulin sensitivity and preservation of β-cell function. How TZDs preserve β-cells is uncertain, but it might involve direct effects via both peroxisome prolifer

Description

Keywords

Keywords: adenosine triphosphate; antidiabetic agent; berberine; compound c; enzyme inhibitor; fatty acid; glucose; hydroxymethylglutaryl coenzyme A reductase kinase; metformin; palmitic acid; pioglitazone; unclassified drug; animal cell; article; controlled study;

Citation

URI

http://hdl.handle.net/1885/38830

Collections

ANU Research Publications

Source

Endocrinology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1210/en.2008-1557

Restricted until

2037-12-31

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Description
01_Lamontagne_Pioglitazone_Acutely_Reduces_2009.pdf (486.6 KB)

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