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Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

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dc.contributor.authorNaz, M.
dc.contributor.authorNasiri, Noushin
dc.contributor.authorIkram, M.
dc.contributor.authorNafees, M.
dc.contributor.authorQureshi, M. Z.
dc.contributor.authorAli, S.
dc.contributor.authorTricoli, Antonio
dc.date.accessioned2023-12-11T03:38:11Z
dc.date.available2023-12-11T03:38:11Z
dc.date.issued2017-10-23
dc.date.updated2022-09-04T08:17:30Z
dc.description.abstractThe work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet-visible (UV-Vis) spectrophotometry. Anticancer activity of Ag-NPs (5-20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.en_AU
dc.description.sponsorshipThis work was supported by the Higher Education Commission (HEC), Pakistan, through 5000 indigenous PhD Scholar Program. The microscope analyses were conducted in the ANU Center for Advanced Microscopy (CAM).en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.citationNaz, M., Nasiri, N., Ikram, M. et al. Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer. Appl Nanosci 7, 793–802 (2017). https://doi.org/10.1007/s13204-017-0615-6en_AU
dc.identifier.issn2190-5509en_AU
dc.identifier.urihttp://hdl.handle.net/1885/309766
dc.language.isoen_AUen_AU
dc.provenanceThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_AU
dc.publisherSpringerOpenen_AU
dc.rights© 2017 The Author(s)en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceApplied Nanoscienceen_AU
dc.subjectDrug loadingen_AU
dc.subjectSeed extracten_AU
dc.subjectCytotoxicityen_AU
dc.subjectAnthelmintic activityen_AU
dc.subjectAg-NPsen_AU
dc.titleEco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast canceren_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
dcterms.dateAccepted2017-10-04
local.bibliographicCitation.issue8en_AU
local.bibliographicCitation.lastpage802en_AU
local.bibliographicCitation.startpage793en_AU
local.contributor.affiliationNaz, M., Government College University Lahoreen_AU
local.contributor.affiliationNasiri, Noushin, College of Engineering and Computer Science, ANUen_AU
local.contributor.affiliationIkram, M., Government College University Lahoreen_AU
local.contributor.affiliationNafees, M., Government College University Lahoreen_AU
local.contributor.affiliationQureshi, M. Z., Government College University Lahoreen_AU
local.contributor.affiliationAli, S., Government College University Lahoreen_AU
local.contributor.affiliationTricoli, Antonio, College of Engineering and Computer Science, ANUen_AU
local.contributor.authoruidNasiri, Noushin, u5207980en_AU
local.contributor.authoruidTricoli, Antonio, u5276175en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor340400 - Medicinal and biomolecular chemistryen_AU
local.identifier.absfor340303 - Nanochemistryen_AU
local.identifier.ariespublicationu4485658xPUB638en_AU
local.identifier.citationvolume7en_AU
local.identifier.doi10.1007/s13204-017-0615-6en_AU
local.identifier.scopusID2-s2.0-85056482667
local.identifier.thomsonIDWOS:000418519100029
local.publisher.urlhttps://link.springer.com/en_AU
local.type.statusPublished Versionen_AU

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