Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer

Thumbnail Image

Date

2017-10-23

Authors

Naz, M.
Nasiri, Noushin
Ikram, M.
Nafees, M.
Qureshi, M. Z.
Ali, S.
Tricoli, Antonio

Journal Title

Journal ISSN

Volume Title

Publisher

SpringerOpen

Abstract

The work aimed to prepare silver nanoparticles (Ag-NPs) from silver nitrate and various concentrations of the seed extract (Setaria verticillata) by a green synthetic route. The chemical and physical properties of the resulting Ag-NPs were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectrometry and ultraviolet-visible (UV-Vis) spectrophotometry. Anticancer activity of Ag-NPs (5-20 nm) had dose-dependent cytotoxic effect against breast cancer (MCF7-FLV) cells. The in vitro toxicity was studied on adult earthworms (Lumbricina) resulting in statistically significant (P < 0.05) inhibition. The prepared NPs were loaded with hydrophilic anticancer drugs (ACD), doxorubicin (DOX) and daunorubicin (DNR), for developing a novel drug delivery carrier having significant adsorption capacity and efficiency to remove the side effects of the medicines effective for leukemia chemotherapy.

Description

Keywords

Drug loading, Seed extract, Cytotoxicity, Anthelmintic activity, Ag-NPs

Citation

Naz, M., Nasiri, N., Ikram, M. et al. Eco-friendly biosynthesis, anticancer drug loading and cytotoxic effect of capped Ag-nanoparticles against breast cancer. Appl Nanosci 7, 793–802 (2017). https://doi.org/10.1007/s13204-017-0615-6

URI

http://hdl.handle.net/1885/309766

Collections

ANU Research Publications

Source

Applied Nanoscience

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

Creative Commons Attribution 4.0 International License

DOI

10.1007/s13204-017-0615-6

Restricted until

Downloads

File
Description
s13204-017-0615-6.pdf (3.24 MB)

DSpace software copyright © 2002-2026 LYRASIS