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The Role of Endoplasmic Reticulum Stress in Nonimmune Diabetes: NOD.k iHEL, a Novel Model of β Cell Death

Date

Authors

Socha, L

Silva, Diego

Lesage, Sylvie

Goodnow, Christopher

Petrovsky, Nikolai

Publisher

New York Academy of Sciences

Abstract

The final common pathway in diabetes development is β cell apoptosis. We herein describe a novel diabetes model based on transgenic NOD.k iHEL mice, wherein male mice develop diabetes due to nonimmune-mediated β cell death. Histology and electron micros

Keywords

Keywords: animal cell; animal experiment; animal model; animal tissue; cell death; cell function; conference paper; controlled study; endoplasmic reticulum; glucose tolerance test; histopathology; male; mouse; non insulin dependent diabetes mellitus; nonhuman; panc ß cell; Cell death; Diabetes; Endoplasmic reticulum (ER) stress; NOD.k iHEL

URI

http://hdl.handle.net/1885/86166

Collections

ANU Research Publications

Source

Annals of the New York Academy of Sciences

Type

Journal article

DOI

10.1196/annals.1288.022

Restricted until

2037-12-31

Downloads

File

Description

01_Socha_The_Role_of_Endoplasmic_2003.pdf (1.97 MB)