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Assignment of the 13 C and 15 N NMR spectra of the antitumour antibiotic streptonigrin

Date

Authors

Harding, Margaret

Anderberg, Pia I

Luck, Ian J

Publisher

John Wiley & Sons Inc

Abstract

The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15N (HSQC, HMBC) and 13C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity.

Keywords

Keywords: antibiotic agent; antineoplastic agent; metal complex; nitrogen derivative; rufocromomycin; antineoplastic activity; article; carbon nuclear magnetic resonance; complex formation; drug structure; nuclear magnetic resonance spectroscopy; structure activity 2,2'-bipyridyl; 13C NMR; 15N NMR; Aminoquinone; Metal complex; NMR; Streptonigrin

URI

http://hdl.handle.net/1885/73519

Collections

ANU Research Publications

Source

Magnetic Resonance in Chemistry

Type

Journal article

DOI

10.1002/mrc.997

Restricted until

2037-12-31

Downloads

File

Description

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02_Harding_Assignment_of_the__13_C_and__2002.pdf (91.75 KB)