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Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

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dc.contributor.authorXu, Xingjun
dc.contributor.authorKim, Hye
dc.contributor.authorChen, Weimin
dc.contributor.authorMa, Xiang
dc.contributor.authorCorrey, Galen
dc.contributor.authorBanwell, Martin
dc.contributor.authorJackson, Colin
dc.contributor.authorWillis, Anthony
dc.contributor.authorCarr, Paul D
dc.date.accessioned2019-04-08T03:57:46Z
dc.date.issued2017
dc.date.updated2019-03-12T07:20:57Z
dc.description.abstractThe title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.en_AU
dc.description.sponsorshipWe thank Jinan University, the Australian Research Council, and the Institute of Advanced Studies for financial support. H. S. K. and G. J. C. are the grateful recipients of scholarships provided by the Australian Government.en_AU
dc.format.extent10 pagesen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1434-193Xen_AU
dc.identifier.urihttp://hdl.handle.net/1885/159300
dc.language.isoen_AUen_AU
dc.provenancehttp://sherpa.mimas.ac.uk/romeo/issn/1434-193X/ Author can archive pre-print (ie pre-refereeing). author can archive post-print (ie final draft post-refereeing) with a 12 months embargo (Sherpa/Romeo as of 8/4/2019)en_AU
dc.provenancehttps://v2.sherpa.ac.uk/id/publication/1692..."The Accepted Version can be archived in a Non-Commercial Institutional Repository. 12 months embargo" from SHERPA/RoMEO site (as at 6/01/2021). This is the peer reviewed version of the following article: [Xu, Xingjun, et al. "Total Syntheses of the Amaryllidaceae alkaloids zephycandidine III and lycosinine A and their evaluation as inhibitors of acetylcholinesterase." European Journal of Organic Chemistry 2017.27 (2017): 4044-4053.], which has been published in final form at https://dx.doi.org/10.1002/ejoc.201700705. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.publisherWiley-VCH Verlag GMBHen_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP170100926
dc.rights© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen_AU
dc.sourceEuropean Journal of Organic Chemistryen_AU
dc.subjectAChE inhibitionen_AU
dc.subjectAlkaloidsen_AU
dc.subjectBiarylsen_AU
dc.subjectCross couplingen_AU
dc.subjectLycosinine Aen_AU
dc.subjectZephycandidine IIIen_AU
dc.titleTotal Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesteraseen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Access
local.bibliographicCitation.issue27en_AU
local.bibliographicCitation.lastpage4053en_AU
local.bibliographicCitation.startpage4044en_AU
local.contributor.affiliationXu, Xingjun, College of Science, The Australian National Universityen_AU
local.contributor.affiliationKim, Hye, College of Science, The Australian National Universityen_AU
local.contributor.affiliationChen, Weimin, Jinan Universityen_AU
local.contributor.affiliationMa, Xiang, College of Science, The Australian National Universityen_AU
local.contributor.affiliationCorrey, Galen, College of Science, The Australian National Universityen_AU
local.contributor.affiliationBanwell, Martin, College of Science, The Australian National Universityen_AU
local.contributor.affiliationJackson, Colin, College of Science, The Australian National Universityen_AU
local.contributor.affiliationWillis, Anthony, College of Science, The Australian National Universityen_AU
local.contributor.affiliationCarr, Paul D, College of Science, The Australian National Universityen_AU
local.contributor.authoruidXu, Xingjun, t1780en_AU
local.contributor.authoruidKim, Hye, u4361491en_AU
local.contributor.authoruidMa, Xiang, u5342100en_AU
local.contributor.authoruidCorrey, Galen, u5025097en_AU
local.contributor.authoruidBanwell, Martin, u9500594en_AU
local.contributor.authoruidJackson, Colin, u4040768en_AU
local.contributor.authoruidWillis, Anthony, u8512028en_AU
local.contributor.authoruidCarr, Paul D, u9206448en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor030503 - Organic Chemical Synthesisen_AU
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciencesen_AU
local.identifier.ariespublicationa383154xPUB7520en_AU
local.identifier.citationvolume2017en_AU
local.identifier.doi10.1002/ejoc.201700705en_AU
local.identifier.essn1099-0690en_AU
local.identifier.scopusID2-s2.0-85025650780
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusAccepted Versionen_AU

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