Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase
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Authors
Xu, Xingjun
Kim, Hye
Chen, Weimin
Ma, Xiang
Correy, Galen
Banwell, Martin
Jackson, Colin
Willis, Anthony
Carr, Paul D
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Wiley-VCH Verlag GMBH
Abstract
The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.
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European Journal of Organic Chemistry
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Open Access