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Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

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Date

2017

Authors

Xu, Xingjun
Kim, Hye
Chen, Weimin
Ma, Xiang
Correy, Galen
Banwell, Martin
Jackson, Colin
Willis, Anthony
Carr, Paul D

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley-VCH Verlag GMBH

Abstract

The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

Description

Keywords

AChE inhibition, Alkaloids, Biaryls, Cross coupling, Lycosinine A, Zephycandidine III

Citation

URI

http://hdl.handle.net/1885/159300

Collections

ANU Research Publications

Source

European Journal of Organic Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1002/ejoc.201700705

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Total Syntheses of Lycosinine A and Zephycandidine III V6 (Final) AAM.pdf (430.67 KB)

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