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Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

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dc.contributor.authorZhao, Chunjiu
dc.contributor.authorRickards, Rodney
dc.contributor.authorTrowell, Stephen Charles
dc.date.accessioned2015-12-13T23:09:25Z
dc.date.issued2004
dc.date.updated2016-02-24T09:47:46Z
dc.description.abstractThe antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/1885/86993
dc.publisherElsevier
dc.sourceTetrahedron
dc.subjectKeywords: 1(15),8(19) trinervitadiene 3alpha,5alpha diol; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol 3,5,18 triacetate; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol 5 acetate; 1(15),8(9) trinervitadi Antibacterial; Diterpene; Nasutitermes triodiae; Termite; Trinervitadiene; Trinervitane
dc.titleAntibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae
dc.typeJournal article
local.bibliographicCitation.issue47
local.bibliographicCitation.lastpage10759
local.bibliographicCitation.startpage10753
local.contributor.affiliationZhao, Chunjiu, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationRickards, Rodney, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationTrowell, Stephen Charles, CSIRO Division of Entomology
local.contributor.authoruidZhao, Chunjiu, u3916804
local.contributor.authoruidRickards, Rodney, v000238
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub16081
local.identifier.citationvolume60
local.identifier.doi10.1016/j.tet.2004.08.065
local.identifier.scopusID2-s2.0-5644302250
local.type.statusPublished Version

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