Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae
Date
2004
Authors
Zhao, Chunjiu
Rickards, Rodney
Trowell, Stephen Charles
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Publisher
Elsevier
Abstract
The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.
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Keywords
Keywords: 1(15),8(19) trinervitadiene 3alpha,5alpha diol; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol 3,5,18 triacetate; 1(15),8(19) trinervitadiene 3alpha,5alpha,18 triol 5 acetate; 1(15),8(9) trinervitadi Antibacterial; Diterpene; Nasutitermes triodiae; Termite; Trinervitadiene; Trinervitane
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Source
Tetrahedron
Type
Journal article
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2037-12-31
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