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Targeting of C-Type lectin-like receptor 2 or P2Y12 for the preention of platelet

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Date

2018

Authors

Flierl, Ulrike
Nero, T.L
Lim, B
Andrews, Robert K
Parker, Michael William
Gardiner, Elizabeth
Peter, Karlheinz

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

Essentials CpG oligodeoxynucleotide (ODN) immuotherapeutics cause undesired platelet activating effects. It is crucial to understand the mechanisms of these effects to identify protective strategies. CpG ODN-induced platelet activation depends on C-type lectin-like receptor 2 (CLEC-2) and P2Y12. Targeting CLEC-2 or P2Y12 fully prevents CpG ODN-induced platelet activation and thrombosis.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/255030

Collections

ANU Research Publications

Source

Journal of Thrombosis and Haemostasis

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/jth.13877

Restricted until

2099-12-31

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01_Flierl_Targeting_of_C-Type_2018.pdf (318.8 KB)

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