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A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation

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dc.contributor.authorJenne, C
dc.contributor.authorKennedy, L
dc.contributor.authorMcCullagh, Peter
dc.contributor.authorReynolds, J
dc.date.accessioned2015-12-13T23:13:50Z
dc.date.available2015-12-13T23:13:50Z
dc.date.issued2003
dc.date.updated2015-12-12T08:35:44Z
dc.description.abstractThe current model of Ig repertoire development in sheep focuses on the rearrangement of a small number (∼20) of Vλ gene segments. It is believed that this limited combinatorial repertoire is then further diversified through postrearrangement somatic hy
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/1885/88305
dc.publisherAmerican Association of Immunologists
dc.sourceJournal of Immunology
dc.subjectKeywords: immunoglobulin; animal cell; animal tissue; article; combinatorial chemistry; controlled study; gene mutation; gene rearrangement; genetic variability; nonhuman; nucleotide sequence; priority journal; sheep; somatic hypermutation; Aging; Amino Acid Sequen
dc.titleA new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation
dc.typeJournal article
local.bibliographicCitation.lastpage3750
local.bibliographicCitation.startpage3739
local.contributor.affiliationJenne, C, University of Calgary
local.contributor.affiliationKennedy, L, University of Calgary
local.contributor.affiliationMcCullagh, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationReynolds, J, University of Calgary
local.contributor.authoruidMcCullagh, Peter, a128091
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110706 - Immunogenetics (incl. Genetic Immunology)
local.identifier.ariespublicationMigratedxPub17943
local.identifier.citationvolume170
local.identifier.scopusID2-s2.0-0037378734
local.type.statusPublished Version

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