A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation
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Jenne, C
Kennedy, L
McCullagh, Peter
Reynolds, J
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American Association of Immunologists
Abstract
The current model of Ig repertoire development in sheep focuses on the rearrangement of a small number (∼20) of Vλ gene segments. It is believed that this limited combinatorial repertoire is then further diversified through postrearrangement somatic hy
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Journal of Immunology