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A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation

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Jenne, C
Kennedy, L
McCullagh, Peter
Reynolds, J

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American Association of Immunologists

Abstract

The current model of Ig repertoire development in sheep focuses on the rearrangement of a small number (∼20) of Vλ gene segments. It is believed that this limited combinatorial repertoire is then further diversified through postrearrangement somatic hy

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Journal of Immunology

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