New insights into the protective power of platelets in malaria infection
Date
2013
Authors
McMorran, Brendan
Burgio, Gaetan
Foote, Simon
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Landes Bioscience
Abstract
Platelets, as well as regulating blood hemostasis, are an important component of thebody's defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodiuminfected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidalfactor, platelet factor 4 (PF4) and the red cell-expressed Duffyantigen molecule as the central players in the parasite killing activity of platelets.
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Keywords
Keywords: Plasmodium falciparum Duffy-antigen; Innate immunity; Malaria; Plasmodium falciparum; Platelet; Platelet factor 4
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Source
Communicative & Integrative Biology
Type
Journal article
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Open Access
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