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New insights into the protective power of platelets in malaria infection

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Date

2013

Authors

McMorran, Brendan
Burgio, Gaetan
Foote, Simon

Journal Title

Journal ISSN

Volume Title

Publisher

Landes Bioscience

Abstract

Platelets, as well as regulating blood hemostasis, are an important component of thebody's defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodiuminfected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidalfactor, platelet factor 4 (PF4) and the red cell-expressed Duffyantigen molecule as the central players in the parasite killing activity of platelets.

Description

Keywords

Keywords: Plasmodium falciparum Duffy-antigen; Innate immunity; Malaria; Plasmodium falciparum; Platelet; Platelet factor 4

Citation

URI

http://hdl.handle.net/1885/153509

Collections

ANU Research Publications

Source

Communicative & Integrative Biology

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.4161/cib.23653

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