The solute carrier 6 family of transporters
Date
2012-09
Authors
Bröer, Stefan
Gether, Ulrik
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Publisher
Wiley
Abstract
The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes
and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis.
Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of
the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric
disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family
transporters.
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Keywords
monoamine transporters, antidepressants, transport mechanism, transporter pharmacology
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Source
British Journal of Pharmacology 167.2 (2012):256-78
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Journal article
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