The solute carrier 6 family of transporters

Date

2012-09

Authors

Bröer, Stefan
Gether, Ulrik

Journal Title

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Volume Title

Publisher

Wiley

Abstract

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

Description

Keywords

monoamine transporters, antidepressants, transport mechanism, transporter pharmacology

Citation

Source

British Journal of Pharmacology 167.2 (2012):256-78

Type

Journal article

Book Title

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