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Notch signaling in the immune system

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dc.contributor.authorHoyne, Gerard
dc.date.accessioned2015-12-13T23:07:18Z
dc.date.available2015-12-13T23:07:18Z
dc.date.issued2003
dc.date.updated2015-12-12T08:08:38Z
dc.description.abstractNotch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.
dc.identifier.issn0741-5400
dc.identifier.urihttp://hdl.handle.net/1885/86148
dc.publisherFederation of American Societies for Experimental Biology
dc.sourceJournal of Leukocyte Biology
dc.subjectKeywords: CD4 antigen; CD8 antigen; interleukin 2 receptor; Notch receptor; ubiquitin; B lymphocyte; bone marrow cell; cell differentiation; cell growth; cell survival; hematopoietic stem cell; human; immune system; nonhuman; priority journal; review; signal transd Development; Haematopiesis; Lymphocytes; Lymphopoiesis
dc.titleNotch signaling in the immune system
dc.typeJournal article
local.bibliographicCitation.lastpage981
local.bibliographicCitation.startpage971
local.contributor.affiliationHoyne, Gerard, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidHoyne, Gerard, u4049538
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationMigratedxPub14925
local.identifier.citationvolume74
local.identifier.doi10.1189/jlb.0303089
local.identifier.scopusID2-s2.0-0348047540
local.type.statusPublished Version

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