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Notch signaling in the immune system

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Date

2003

Authors

Hoyne, Gerard

Journal Title

Journal ISSN

Volume Title

Publisher

Federation of American Societies for Experimental Biology

Abstract

Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.

Description

Keywords

Keywords: CD4 antigen; CD8 antigen; interleukin 2 receptor; Notch receptor; ubiquitin; B lymphocyte; bone marrow cell; cell differentiation; cell growth; cell survival; hematopoietic stem cell; human; immune system; nonhuman; priority journal; review; signal transd Development; Haematopiesis; Lymphocytes; Lymphopoiesis

Citation

URI

http://hdl.handle.net/1885/86148

Collections

ANU Research Publications

Source

Journal of Leukocyte Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1189/jlb.0303089

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