The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
Date
2011-12-08
Authors
Roper, Kimberley A
Lange, Heiko
Polyzos, Anastasios
Berry, Malcolm B
Baxendale, Ian R
Ley, Steven V
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Volume Title
Publisher
Beilstein-Institut
Abstract
Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.
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Keywords
appel reaction, bromination, flow chemistry, solid-supported reagent, triphenylphosphine monolith
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Source
Beilstein Journal of Organic Chemistry
Type
Journal article
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Open Access
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