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Permeation Dynamics of Chloride Ions in the CIC-O and CIC-1 Channels

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Date

2004

Authors

Corry, Ben
O'Mara, Megan
Chung, Shin-Ho

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels.

Description

Keywords

Keywords: amino acid; chloride ion; article; chemical analysis; chemical structure; chloride channel; controlled study; ion conductance; ion transport; molecular dynamics; nonhuman; structure analysis

Citation

URI

http://hdl.handle.net/1885/78176

Collections

ANU Research Publications

Source

Chemical Physics Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.cplett.2004.01.072

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