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Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells

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Date

2013

Authors

Narayan, Priyanka
Ganzinger, Kristina A.
McColl, James
Weimann, Laura
Meehan, Sarah
Qamar, Seema
Carver, John
Wilson, Mark
St. George-Hyslop, Peter
Dobson, Christopher M.

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Oligomers of the 40 and 42 residue amyloid-β peptides (Aβ40 and Aβ42) have been implicated in the neuronal damage and impaired cognitive function associated with Alzheimer's disease. However, little is known about the specific mechanisms by which these

Description

Keywords

Keywords: Alzheimer's disease; Cell surfaces; Cellular response; Cognitive functions; Hippocampal cells; Live cell; Molecular chaperones; Nanomolar concentration; Neuronal cell; Neuronal damage; Protein aggregates; Quantitative study; Sensitive method; Single-molec

Citation

URI

http://hdl.handle.net/1885/62225

Collections

ANU Research Publications

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja3103567

Restricted until

2037-12-31

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Description
01_Narayan_Single_molecule_2013.pdf (3.13 MB)

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