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Resolution and improved synthesis of (±)-arsenicin A: a natural adamantane-type tetraarsenical possessing strong anti-acute promelocytic leukemia cell line activity

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Date

2012

Authors

Lu, Di
Coote, Michelle
Ho, Junming
Kilah, Nathan
Lin, Ching-Yeh
Salem, Geoffrey
Weir, Michelle
Willis, Anthony
Wild, Stanley (Bruce)
Dilda, Pierre J

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The resolution and improved synthesis of the naturally occurring, adamantane-type, tetraarsenical (±)-Arsenicin A is reported. The five-step synthesis of (±)-Arsenicin A from methylenebis(phenylarsinic acid) affords (±)-Arsenicin A as air-stable, color

Description

Keywords

Keywords: Air-stable; Asymmetric unit; Chiralpak IA; Colorless crystals; Enantiomeric purity; Glioblastomas; Gold standards; High-level ab initio calculations; Inorganic oxides; Inversion center; Leukemia cells; Methylene groups; Naturally occurring; Oxygen atom; P

Citation

URI

http://hdl.handle.net/1885/20898

Collections

ANU Research Publications

Source

Organometallics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/om201180d

Restricted until

2037-12-31

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Description
01_Lu_Resolution_and_improved_2012.pdf (607.88 KB)

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