Resolution and improved synthesis of (±)-arsenicin A: a natural adamantane-type tetraarsenical possessing strong anti-acute promelocytic leukemia cell line activity

Lu, Di; Coote, Michelle; Ho, Junming; Kilah, Nathan; Lin, Ching-Yeh; Salem, Geoffrey; Weir, Michelle; Willis, Anthony; Wild, Stanley (Bruce); Dilda, Pierre J

Resolution and improved synthesis of (±)-arsenicin A: a natural adamantane-type tetraarsenical possessing strong anti-acute promelocytic leukemia cell line activity

Date

2012

Authors

Lu, Di

Coote, Michelle

Ho, Junming

Kilah, Nathan

Lin, Ching-Yeh

Salem, Geoffrey

Weir, Michelle

Willis, Anthony

Wild, Stanley (Bruce)

Dilda, Pierre J

Publisher

American Chemical Society

Abstract

The resolution and improved synthesis of the naturally occurring, adamantane-type, tetraarsenical (±)-Arsenicin A is reported. The five-step synthesis of (±)-Arsenicin A from methylenebis(phenylarsinic acid) affords (±)-Arsenicin A as air-stable, color